Fly spray（also called insecticide spray or insect killer spray）is a chemical insecticide that comes in an aerosol can that is sprayed into the air to kill flies. Fly sprays will kill various insects such as house flies and wasps.

Fly spray contains chemicals (including many organophosphate compounds) that bind to and permanently block the action of an enzyme called acetylcholinesterase. Acetyl choline (ACh) is the nerve transmitter substance released by motor neurones (at a site called the neuromuscular junction) to stimulate muscle contraction. The muscles relax (stop contracting) when the ACh is removed from the neuromuscular junction (NMJ) by the action of acetylcholinesterase. By inhibiting the cholinesterase the insect can no longer break down ACh in the NMJ and so its muscles lock up in a state of tetany (continuous contraction) making flying and respiration impossible, and the insect then dies of asphyxiation.

In the United States, fly sprays often contain the powerful insect toxin dichlorvos which is often targeted by environmental groups as a carcinogenic compound.

There is an urban legend circulated on the Internet recommending that wasp spray be used in the place of pepper spray.

Using Pesticides Spray Products Safely and Correctly

In addition to reading and following the label directions, consider these tips when using pesticides:

• Make sure kids, pets, and anyone non-essential to the application is out of the area before mixing and applying pesticides.
• Be sure to wear clothing that will protect you when using pesticides. Consider wearing a long sleeve shirt, long pants, and closed-toe shoes in addition to any other protective clothing or equipment required by the label.
• Mix pesticides outdoors or in well-ventilated areas.
• Mix only what you need to use in the short term to avoid storing or disposing of excess pesticide.
• Be prepared for a pesticide spill. Have paper towels, sawdust or kitty litter, garbage bags, and non-absorbent gloves on hand to contain the spill. Avoid using excessive amounts of water, as this may only spread the pesticide and could be harmful to the environment.
• Read the first aid instructions on the label before using the product. Have the telephone number for the Poison Control Center (1-800-222-1222) available in case you have additional questions.
• Remove personal items, such as toys, clothing, or tools from the spray area to avoid contamination.
• When spraying pesticides indoors, make sure the area is well ventilated.
• When applying pesticides as a spray or dust outside, avoid windy conditions and close the doors and windows to your home.
• After using pesticides, wash your hands before smoking or eating.

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